Full Propagation of Analytical Uncertainties in ? ₄₇ Measurements

Clumped-isotope measurements in CO 2 and carbonates (? 47) present a number of technical challenges require correcting for various sources analytical non-linearity. For now we lack formal description the errors associated with these correction steps, which are not accounted most data processing methods currently use. Here formulate quantitative ? 47 error propagation, fully taking into account standardization their properties. We describe strategies, along assumptions they rely on, context this model, propose new, pooled approach designed to yield more robust/accurate corrections. User-friendly online resources an open-source Python library also provided facilitate use models. Among other uses, mathematical framework described here may be helpful improve protocols (e.g., anchor/unknown ratios) inform future efforts define community reference materials.